SYNTHESIS AND SCREENING OF 2-HYDROXYN-(2,41-DIOXOSPIRO [INDOLINE-3,21-THIAZOLIDIN]-31-YL) BENZAMIDES FOR ANTIINFLAMMATORY ACTIVITY

Author(s): N.Saritha Devi1 and Manda Sarangapani*

Abstract: A novel synthesis of 2-hydroxy-N-( 2,41-dioxospiro[indoline-3,21-thiazolidin]-31-yl) benzamide derivatives was synthesized by cyclization of isatin hydazones with thioglycollic acid. The synthesized compounds were characterized by spectral data (IR, 1HNMR, MASS) and evaluated for In-vitro, In-vivo anti-inflammatory activity. The test compounds exhibited significant potency to inhibit COX-2 enzyme values between46.23±0.38to73.24±0.35, Among the tested compounds VIi(R=5,6-dichloro), VI f (R=5-F), VI b (R=5-Cl), are considered to possess more potent anti-inflammatory activity when compared to standard drug indomethacin. By in-vitro anti-inflammatory activity the compound VIi (R=5,6-dichloro) VI f (R=5-F), VI b (R=5=Cl) and VIH(R=5-Br) are considered to possess more potent anti-inflammatory activity when compared to standard drug indomethacin.

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