ANTICANCER PROPERTY OF SIMPLE ASCIDIAN PHALLUSIA NIGRA SAVIGNY, 1816 AGAINST A-549 CANCER CELL

Author(s): Victor Shanthini Deepa and Gnanakkan Ananthan

Abstract: Background: Lung cancer is one of the most prevalent disease affects the human beings. To assess the anticancer activity of the ethyl acetate, ethanol, methanol, chloroform and aqueous extract of the simple ascidian Phallusia nigra against human lung cancer cell lines (A-549). The extract administration at 100 l, 50 l, 25 l, 12.5l, 6.25 l in 100 l of 5% MEM. 76% of cytotoxicity was observed in cells cultivated at 100 l concentration. There was a dose dependent increase in number, inhibition of cancer cells and decrease in size of tumor volume. A high reduction in tumor was noted. In vivo studies indicate the presence of bioactive compounds in Phallusia nigra with anticancer property against A-549 cells.

PAGES: 136-148  |  27 VIEWS  39 DOWNLOADS