FORMULATION AND EVALUATION OF DOMPERIDONE ORAL JELLY

Author(s): Ruheena Taranum* and Sirisha Mittapally

Abstract: Oral medicated jelly is a novel oral dosage form. There is need to develop such dosage form in order to overcome difficulties faced by paediatric and geriatric patients in administration of conventional dosage form. It is highly beneficial for individuals with swallowing difficulties. Oral jelly can be chewed effortlessly & dissolves easily in saliva without any need of water for ingestion making it unique from other dosage forms. Further patients get fascinated by its appearance & soft texture resulting in high patient acceptance. In the present research work Domperidone jelly was formulated to provide faster relief from nausea & vomiting compared to other dosage forms. Jelly formulation is prepared using sucrose, gelatine, citric acid, sodium citrate, sodium benzoate by heating & congealing method. It is evaluated for appearance, weight variation, pH, synergesis, drug content, & dissolution. Optimized formulation has shown drug release of 98.39% in 25minutes.Medicated jelly (F5) has shown effective drug release compared to the soft chew formulation (F9). The stability studies on optimized formulation (F5) was carried out as per ICH guidelines & has shown acceptable result.

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