PREPARATION AND IN VITRO EVALUATION OF HIGHLY POROUS GASTRORETENTIVE FLOATING BECLOMETHASONE DIPROPIONATE TABLETS

Author(s): Ramya Bhanu.B*, Mangilal.T, Ravi Kumar.M and Naveen.J

Abstract: The present study is aimed to formulate floating gastro retentive (GR) tablets containing beclomethasone dipropionate using a sublimation material for prolongation of gastric residence time. Three different ratios of hydroxyl propyl methyl cellulose (HPMC) K4M is used in three different methods for the preparation of tablets. In this case, the drug release from tablet was highly dependent on the polymer concentrations. Camphor, the sublimation material is used in the preparation of GR tablets. Camphor changes to pores in the tablet during the sublimation process. As the camphor gets sublimed, floating properties and density of tablets were affected by the sublimation of camphor. Gastro retentive floating beclomethasone dipropionate tablets which were prepared floated for over 24 hrs and had no floating lag time. Therefore, as the concentration of camphor in the tablet matrix increases, the hardness of the tablet decreased after sublimation. Release profiles of the drug from the GR tablets were not affected by tablet density or porosity.

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