In vitro Antidiabetic, Antibacterial and Antioxidant Activity of the Alcoholic Extracts of Momordica charantia L Fruits

Author(s): Mohammad Sayful Islam, Md. Golam Mucktady, Netish Kumar Kundo, Mohammad Johirul Islam, Md. Moyen Uddin PK

Abstract: Objective: The aim of the study was to assess in vitro antidiabetic, antibacterial and antioxidant activity of alcoholic extracts of Momordica charantia L Fruits. Method: Momordica charantia L Fruits extracts were prepared by soaking in methanol and ethanol. The extracts were used for evaluating their antidiabetic, antibacterial and antioxidant activity using dinitrosalicylic acid method, disc diffusion and DPPH assay respectively. The results were compared with standard compounds. Results: The ethanolic extract of Momordica charantia L Fruits showed maximum α-amylase inhibition (77±0.23 % of glucose release inhibition at 2.0 mg/mL) and DPPH radicals scavenging (IC90;769.88 mg/mL) activity at prescribed concentrations dependent manner. Methanolic extract showed nearly similar activity. The ethanolic and methanolic extracts also exhibited a significant extent of inhibition on the growth of bacteria. Conclusion: Momordica charantia L Fruits can be further studied to isolate the phytocompounds responsible for the antidiabetic, antibacterial and antioxidant activity.

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