Design, Prepare and Characterization of Nefidipine Buccal Patches

Author(s): Y. Krishna Reddy*, B. Deepika and L. Ravali

Abstract: Research work was design, prepare and characterization of antihypertensive buccal patches. Nefidipine used in treatment of blood pressure, congestive cardiac failure and angina. BDDS can be effectively utilized for the drug which undergoes first pass metabolism. The quality of API with regard to solubility and short half-life makes this drug as a suitable candidate for administration by Buccal route. These Nefidipine buccal patches were optimized for their thickness, folding endurance, content uniformity and release rate of the drug. Drug and excipient compatibility measured by using FTIR. Release rate of the drug were carried out with Franz diffusion cell utilizing pH 6.8 phosphate buffers as drug release medium.

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