Effect of Apoptosis on Human Breast Cancer Cell Line (MCF-7 and MDA-MB231) Using Curcuma longa

Author(s): Anitha Joice*, Dilla Jose, J. Manju Bashini and P. Senthilkumaar

Abstract: Cancer cells usually have increased cell proliferation; have ability to survive in unique environment and decreased apoptosis. Decreased apoptosis gives the cancer cells a survival advantage. All cells showed a small base line apoptotic level. Treatment of cancer cells with curcumin significantly increased apoptosis by Caspase 3/7 assay, Annexin IV assay and tunel assay suggesting that both early and late apoptotic events are triggered by curcumin. Increased apoptosis by curcumin may be used to kill the cancer cells and thereby help in treatment of cancer. The overall results obtained in the study point out that the active molecule present in Curcuma longa have considerable consequence on the survival of human breast cancer cell lines. Finally, it is concluded that curcuminoids are a group of phenolic compounds isolated from the rhizome of Curcuma longa has various pharmacological properties. They exhibit growth inhibitory effects on a broad range of tumors and act as potent anticancer, anti-inflammatory and analgesic agent and more research should be carried out and this data should be made accessible for both health care providers and patients for safe anticancer treatments.

PAGES: 73-84  |  30 VIEWS  58 DOWNLOADS