EVALUATION OF ANTIHYPERTENSIVE ACTIVITY OF IRBESARTAN SOLID DISPERSIONS BY NON-INVASIVE TECHNIQUE

Author(s): Ramu A, Vineela S*, Vidyadhara S and Sowjanya Lakshmi B

Abstract: Aim: Solid dispersions in hydrophilic carriers have attracted considerable interest of improving the dissolution rate and possibly bioavailability of a range of hydrophobic drugs. The aim of present study was made to improve the solubility of Irbesartan by formulating into solid dispersions by using a polymer, kollidon VA64, was further subjected to anti- hypertensive evaluation in Wistar rats. Method: Solid dispersions were prepared by using physical mixing, solvent evaporation and kneading methods using Kollidon VA64 as a polymer at different ratios. All the solid dispersions were found to be stable and evaluated for drug release studies. Results: Majority of the formulations displayed first order release kinetics and were found to be linear with R2 values in the range of 0.991-0.994. FTIR and DSC analysis results revealed no major interactions between the drug and the excipients used in the solid dispersions. The optimized solid dispersion was evaluated for its antihypertensive activity by using noninvasive tail cuff method. Conclusion: It was observed that Irbesartan solid dispersion (IK3) showed more anti- hypertensive activity in deoxycorticosterone acetate (DOCA) salt induced hypertensive rats than glucose induced hypertensive rats when compared with standard Irbesartan and other formulations.

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