AN EMERGENT PLANT ‘LEUCAS INDICA’ PLAYS A POTENTIAL ROLE IN TREATMENT OF TYPE II DIABETES

Author(s): Sunitha Thalugula and *Yellu Narsimha Reddy

Abstract: The current study deals with anti-diabetic and pancreatic protective effects of Leucas indica variety Nagalapuramiana extracts in high fat diet (HFD) and streptozotocin (STZ) induced type 2 diabetes model. Ethylacetate extracts were orally administered at the dose of 10, 30 and 100 mg/kg and metformin was used as standard anti-diabetic drug at 10 mg/kg dose orally. Blood glucose, lipid profiles, pancreatic parameters and oral glucose tolerance test (OGTT) were performed. Treatment with extracts resulted significant dose dependent and time dependent decrease diabetes incidence with marked reduction in the blood glucose levels. Glucose tolerance was greatly improved after treatment with plant extracts with high dose group producing effects similar to standard drug mediated beneficial effects. Histopathological studies also indicated pancreatic beta cell protective effects of Leucas indica variety Nagalapuramiana extracts with increased beta cell number and size. Our results demonstrate that Leucas indica variety Nagalapuramiana can be possible remedy to treat type 2 diabetes and associated complications.

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