A Review on Stimuli-Responsive Polymers and Recent Strategies for Treating Cancer Based on Stimuli Responsive Nanocarriers (Review Article)

Author(s): Gaikwad A.R* and Salunke K.S

Abstract: This review describes some commercially accessible stimuli-responsive polymers of synthetic and natural origin, and their applications in drug delivery with the help of nanocarriers and treating cancer like dosages. The polymers of natural origin such as gelatin, albumin, cellulose, and chitosan are found to exhibit both pH-responsive and thermo-responsive properties and these features of the biopolymers impart sensitivity to act differently under different pH and temperatures conditions. Stimuli-responsive biomaterials that include logic gates maintain excellent potential for detecting and responding to pathological markers as phase of medical treatments that they are not perfecting. Some virtually essential thermo-responsive polymers such as poly (N-isopropyl acrylamide) (pNIPAAM)and Pluronic F127 (PF127) of synthetic origin has been mentioned in the review. In recent years, a lot of progress has been impelled in stimuli-responsive nanocarriers, that might response to the pathological and intrinsic physicochemical factors in diseased regions to extend the specificity Currently, various nanocarriers are designed with physicochemical changes in responding to external stimuli, like ultrasound, thermal, light, and magnetic field, as well as internal stimuli, including hydrogen ion concentration. This review has summarized the general strategies of developing stimuli-responsive nanocarriers and recent advances, presented their applications in drug delivery, treatment and tumor diagnosis with help of stimuli-responsive polymers. Owing to precise stimuli response, stimuli-responsive drug delivery systems will management drug release, thus on improve the curative effects, reduce the harm of organs and normal tissues and reduce the side effects of traditional anti-cancer medicine.

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