Floating Oral in situ Gel, An Approach of Gastro-Retentive Drug Delivery System: A Review (Review Article)

Author(s): Dipal R. Prajapati*, Raviraj R. Prajapati Helit P. Jain and D. B. Meshram

Abstract: The Floating Drug Delivery System (FDDS) are invented to retain the drug in the stomach and applicable for drugs with poor solubility and low stability in intestinal fluids. The Main work of FDDS is making the dosage form less dense than the gastric fluids to make it float on them. This research is directed towards overcoming physiological adversities such as short gastric residence time (GRT) & unpredictable gastric emptying time (GET). The main contribution of this work lies in the study of Floating Drug delivery System with its types and mechanisms. This study shall help to learn about gastric retention, various approaches to produce gastro retention of drug delivery system with special discussion on floating in-situ gel. This offers various advantages like prolonged and sustained action in comparison to conventional drug delivery system.

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