Effect of Polyherbal Formulation on Learning and Memory in Animal Models of Alzheimer’s Disease (Research Article)

Author(s): Shraddha Desai*, Sandeep Chandakavate, Savita Kulkarni, Santosh Rathod and Krishna Deshpande

Abstract: Objective: - The current study was investigated on sumanas (SMS) a polyhebral formulation against colchicines induced animal model of Alzheimer’s disease. Methods: -The memory enhancing activity of SMS was demonstrated by in vivo methods like Morris water maze and elevated plus maze using colchicines induced model cause cognitive impairment and memory demolition. The cognitive impairment activity of SMS was evaluated by serum levels GSH, LPO, CAT, AChE content of the brain. Results and Discussion: - the Effect of Sumanas in colchicine induced Alzheimer model has showed, a significant alteration in biochemical parameters i.e., serum enzymes namely, LPO, GSH, CAT, AChE levels and in was observed. Oral administration of Sumanas (25, 50, 100 mg/Kg) was found increases LPO, CAT and AChE levels by dose dependent manner. By this alteration in biochemical estimation confirmed that SMS has positive effective in treatment of AD. The observed neuroprotective property of herbal formulation SMS was due to presence of phytochemicals. Conclusion: - SMS was already used herbal medicine in the cognitive patients which shown improved the cognitive impairment through memory enhancing property. Due to lack of evidence the study was undertaken and concluded by estimation of biochemical markers. SMS has found significantly neuroprotective in colchicines induced Alzheimer’s disease.

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