Evaluation of Anticonvulsant Activity of Prunus amygdalus Batsch Kernels in Experimental Animal Model (Research Article)

Author(s): R. Geethu*

Abstract: Prunus amygdalus batsch kernels are traditionally used as a remedy for various diseases. The aim of the present study is to evaluate the anticonvulsant activity of Prunus amygdalus batsch kernels in mice. The fine suspension of Prunus amygdalus kernels was used for assessing the anticonvulsant activity using various method by oral administration of two different doses of the extract (200mg/kg p.o and 400 mg/kg p.o). Preliminary phytochemical screening was carried out for determining the chemical constituents present in it. The anticonvulsant activity was evaluated by Maximal electroshock (MES) induced convulsion and Pentylenetetrazole (PTZ) induced convulsion. Biochemical parameters such as malondialdehyde (MDA) and reduced glutathione (GSH) were estimated in the isolated brain after completion of the anticonvulsant studies. The datas obtained from the results showed that the suspension possesses anticonvulsant activity at different doses of the extract (200mg/kg p.o and 400 mg/kg p.o) in a dose dependent manner at *P<0.05, **P<0.01, ***P<0.001 when compared with the positive control. Maximum activity was observed in 400mg/kg p.o. Flavanoids present in the kernels which possess antioxidant and anticonvulsant effect may be responsible for the anticonvulsant activity shown by the plant extract.

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