Formulation and Evaluation of Dapsone Nanosponge Topical Gel (Research Article)

Author(s): Khalandar R Mulla*, Vinayak K, Omkarswamy Maradimath, Prashanth K U And Megha C M

Abstract: Recent advances in nanotechnology paved path for design of nanogels with many potential applications in the field of nanomedicine. Nanogels being dispersions of hydrogel nanoparticles or nano sponges offer high drug loading compared to other nanocarriers and are thus suitable for solving issues related to stability, solubility and delayed release of actives and to formulate drug delivery systems for various administration routes besides the oral one. Development of Nano sponges as topical drug delivery systems is presented in this dissertation. where we formulated Dapsone nano sponge based topical gel using ethyl cellulose as polymer and polyvinyl alcohol as surfactant with different concentration. Which were evaluated for percentage yield, drug entrapment efficiency, surface morphology, particle size analysis and in-vitro drug release among all 6 different formulations F5 batch considered as the best with 76% of drug entrapment efficiency and with greater percentage drug release of 96.80% at the end of 12hrs. From the SEM analysis its concluded that nano sponges are spherical, discreet with smooth surface, and particle size was found to be 91.22 (d.nm) by zeta sizer. The nano sponges of the best formulation F5 was loaded into the Carbopol 394P gel which were evaluated for viscosity, spreadability, pH, extrudability, drug content, in-vitro drug diffusion study, release kinetics and stability studies. Finally, we concluded that prepared dapsone nano sponge topical gel shows promised drug release and good stability.

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