Development and In vitro Evaluation of Capecitabine Loaded Polymeric Nano Particles for Tumor Targeted Drug Delivery Systems (Research Article)

Author(s): Pittala Pavithra*, Sheri Sowmya, Patnam Deepika and Syed Kashif Mohiuddin and P. Vishnupriya

Abstract: Nanoparticles are formulated to target the drug to the specific organ site and to control the rate of drug delivery. The main aim of this study is to achieve prolonged release of Capecitabine such that the dosing frequency of the drug can be reduced by which we may decrease the side effects and improve the patient compliance. Investigation of the preparation, characterization and in-vitro delivery of the nanoparticles was carried out. The different formulations of with different concentration of drug-polymer and surfactant were examined and finalized. Encapsulation efficiency of nanoparticles ranged between 68% - 81%. The prepared particles showed good drug-loading capacity. The invitro release studies showed that after the initial burst, all of the drug-loaded batches provided a continuous and slow release of the drug. The present study revealed that ionic gelation technique followed by sonication can be used as an effective tool for preparation of Capecitabine nanoparticles. Formulation (F-2) showed the highest encapsulation efficiency i.e., 81%. It was found that as the concentration of chitosan increased, the % of encapsulation efficiency was also increased.

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