In vitro Assessment of Cytotoxicity and Antioxidant Activities of Sida Ovata Forssk Leaves Extract (Research Article)

Author(s): Prashanth Kumar Nandru, Baswaraju Macha, Narsimha Reddy Yellu*

Abstract: Sida cordata is plant of malvaeceae, native to India. The present study was aimed to focus on antioxidant and cytotoxic properties of methanolic and acetone extract of Sida cordata. The antioxidant activity was evaluated by DPPH free radical scavenging method, estimating total phenolic as well as flavonoid content and cytotoxic properties was evaluated by using brine shrimp lethality bioassay. For free radical scavenging IC50 190μg/ml compared to ascorbic acid IC50 10 μg/ml. The total phenolic content ranged from 145.45 mg/g to 130mg/gm of dry weight of extract, expressed as gallic acid equivalents. The cytotoxicity was reported in terms of lethality concentration LC50 for crude extract was 263.02 μg/ml. Sida cordata can be regarded as promising candidates for natural plant sources of antioxidants as well as cytotoxic compound with significant value and can be harnessed and purified into useful therapeutic drugs.

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