Glomerular Dysfunction in Type 2 Diabetes Mellitus-A Comparison of Early Onset with Late Onset Type 2 Diabetes Mellitus (Research Article)

Author(s): Velu Malarkodi*, Ramanathan Freethi, and Duuraisamy Alamelumangai

Abstract: The India State-Level Disease Burden Initiative Diabetes study collaborators reported that Tamil Nadu had the highest the prevalence of Diabetes in 2016. CURES Study done in Urban South Indian (Chennai) Population reported prevalence of overt nephropathy was 2.2% and microalbuminuria was 26.9%. A higher prevalence of hyperfiltration has been reported in certain ethnic groups, such as Pima Indians, African Americans, Asians and Polynesians, than in Caucasians. The prevalance and complication of early onset type 2 diabetes is understudied in South India. Our aim was to assess the glomerular function of the kidneys in Early Onset Type 2 Diabetes Mellitus. Diabetics attending the NCD outpatient for routine check - up were included in this study. The biochemical parameters were analysed in automated autoanalysers photometrically. Glomerular Filtration was estimated using Modification of Diet in Renal Disease equation (MDRD). The mean e GFR was increased and the percentage of mild to moderate damage of kidney was more indicating renal damage in early onset diabetes. Lower creatinine levels were noted in early onset diabetics indicating glomerular hyperfunctioning of the kidneys which precedes renal damage. The eGFR was increased considerably in obesity category 2. Glomerular hyperfiltration was considerably more in early onset diabetics. Liu et al found in an Asian T2DM cohort, with 1189 patients with early-onset DM had higher risk of progressive CKD and had both albuminuria and renal function deterioration. The decreasing trend of eGFR is a better marker and indicator of the Diabetic Nephropathy.

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