Formulation and Evaluation Oral Dispersible Tablets of Vidarabine (Research Article)

Author(s): Akula Priyanka*, Vishwanadhula Pavani, Mohammad Ismail, Ampati Srinivas

Abstract: In the present work, taste masking of Vidarabine was carried out by using HP-β-CD inclusion complex. These taste-masked complexes were further formulated into the Oro dispersible tablet by the direct compression method using Ac-Di-Sol and Avicel as a super disintegrant. Vidarabine is used in the treatment of AIDS. This research has described the production of a taste masked dosage form from initial determination of threshold bitterness concentration of the pure drug through to the development of a final taste masked prototype formulation. It was found that the taste masked 1:2 ratio of LMV: HP-β-CD inclusion complex increases the bulk of final ODT blend (above 1000 mg) which is not feasible for formulation of ODTs. So, in this study the ODTs of LMV: HP-β-CD inclusion complex (1:1 ratio) showing acceptable bitterness in human taste panel studies was used in formulation of ODTs. In all formulations, the dispersion produced was soft (without grittiness) with a good mouth feel, and the bitter taste was fully masked. In vitro drug release profile of all optimized ODT formulations showed around 90% of drugs release within 10 to 15 minutes in acidic buffer (pH 1.2), implying that the drug will be absorbed fast, increasing the chances of bioavailability. A three-month stability analysis was carried out. For the optimized formulations, there was no noticeable difference in disintegration time, hardness, friability, or drug content.

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