A Complete Analysis of The Synthesis and Pharmacological Effects of Pyrazolone Derivatives

Author(s): Justin Jacob Thomas*, Presanna kumaran P N, Santhosh M Mathew, Joshny Varghese and Rincy Meriyam Varghese

Abstract: Pyrazolone is a five membered lactam ring, containing two nitrogen and one ketonic group in its structure. Pyrazalone’s possesses anti-microbial, anti-fungal, antioxidant, anti-inflammatory, cytotoxicity, analgesic, anti-pyretic and anti-depressant activities. They also serve as precursors for dyes, pigments, pesticides, and chelating agents. Generally, the condensation of hydrazines with β-ketoester compounds is the classical method for the synthesis of pyrazolones, followed by reaction with various benzaldehyde derivatives. It is an exciting area of pharmaceutical chemistry to research the biological evaluation of pyrazolone derivatives. This review article provides information about different synthetic schemes and biological activities of various pyrazolone derivatives.

PAGES: 149-161  |  38 VIEWS  78 DOWNLOADS