Formulation and Evaluation of Polyherbal Topical Gel for Treatment of Acne (Research Article)

Author(s): Adnan Siddiqui, Shaikh Aaqueeb, Sk Shehzad, Mayur Jaysawal, Quazi Majaz, G. J. Khan

Abstract: Nowadays, cosmetics are becoming more high demand in daily life, and it was used frequently by many of people per year. Mankind uses various products to enhance beauty and elegance to look young and charming. Thus, cosmetics play a vital role in human life. Now days, herbal cosmetic are widely used because of the belief that they have fewer side effects and better safety. Acne vulgaris is a prevalent skin disorder affecting millions of individuals worldwide, characterized by the formation of comedones, papules, pustules, and nodules. The multifaceted nature of acne involves sebum overproduction, inflammation, and microbial colonization, necessitating the search for effective and safe therapeutic options. Natural compounds, such as protocatechuic acid (PCA) and curcumin, have emerged as promising candidates for managing acne due to their anti-inflammatory, antioxidant, and antimicrobial properties. The combination of PCA and curcumin presents an intriguing prospect for acne management. Their complementary actions, including anti-inflammatory, antioxidant, and antimicrobial effects, could synergistically address multiple aspects of acne pathogenesis. However, optimal dosages, formulations, and safety profiles need further exploration. In conclusion, protocatechuic acid and curcumin exhibit promising potential as anti-acne agents due to their multifaceted properties. While preclinical studies highlight their efficacy in modulating inflammation, oxidative stress, and microbial growth, clinical trials are needed to validate their effectiveness in human subjects. Embracing these natural compounds could lead to the development of novel, holistic approaches for acne treatment, potentially reducing the reliance on conventional therapies with associated side effects.

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