Design, Prepare, and Characterization of Erythrina Variegata Loaded Solid Lipid Nanoparticles (Research Article)

Author(s): N. Umarani*, P. Sruthi, M. Likitha, P. Sanjeetha and R. Kotireddy

Abstract: The goal of this study was to assess the efficacy of a method based on the creation of solid lipid nanoparticles as an innovative formulation of Erythrina Variegata with enhanced therapeutic efficacy. The Erythrina Variegata solid lipid nanoparticles were created using the Sonicator to apply ultrasonic energy during the emulsification solvent evaporation process. The numerous formulations with varied drug-lipid and surfactant ratios were analysed and improved. Erythrina Variegata solid lipid nanoparticles containing soy lecithin were created using the solvent evaporation method, then the particle size was decreased by sonication. Particle size, surface morphology by SEM, drug excipient compatibility by FTIR, and in-vitro drug release experiments were used to characterize the produced nanoparticles. The formulation with the best encapsulation efficiency was (F-4) A drug encapsulation effectiveness of up to 95.36 % has been attained in this study. It was discovered that the efficiency of encapsulation improved along with the soy lecithin content. According to the results of the current investigation, the manufacture of Erythrina Variegata solid lipid nanoparticles can be done using a solvent evaporation process followed by sonication.

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