Formulation and Evaluation of Cefixime Loaded Grafted Gellan Gum Tablet (Research Article)

Author(s): Tejaram*, Rajesh Sharma, Prashant Purohit, Sanju and Kashi Ram

Abstract: The objective of the present work is to design sustained release tablets of cefixime by incorporating drug with polymer using microwave assisted graft co-polymerization method. In the present study, Gellan gum was used as a polysaccharide and grafted with acrylamide to make a sustained release formulation of cefixime which can solve mainly problem associated with multiple dose frequency and it can also increase patient compliance. The effect of combination of polymers on parameters like release pattern, release mechanism of the drug were studied. Preparation of total Seven formulation A1, A2, A3, A4, A5, A6 and A7 each containing gellan gum and acrylamide. The characterization of optimized formulation A6 was evaluated for Average time (75 sec) , weight of grafted gum (3.029 gm), % yield (84.138%) ,% Grafting (202.9%) and % Grafting Efficiency (57.971%). Cefixime matrix tablets were formulated successfully by changing the excipient amount in four batches A6a, A6b, A6c, A6d and evaluated for the various parameters as per Indian Pharmacopoeia like Thickness (3.37±0.588 mm), Weight Variation (405±2.36 mg), Hardness (6.3Kg/cm2), Friability (0.44% weight loss), Disintegration Time (4.25±0.110 min), and Uniformity of content (96.022±0.113 %). In vitro release profiles of all batches were carried out in simulated gastric fluid pH 1.2 and simulated intestinal fluid pH 7.2 for upto 10 hr. From in vitro release studies, it was found that 81% drug was released in A6c in 10 h. From the result it was confirmed that grafting formed gives sustain drug delivery system.

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