Overview of Genetics: Breast Cancer and Herbal Treatment (Review Article)

Author(s): Mrunal D. Bhagat*, Divya G. Thite, Abhishek A. Bhosale and Sujit M. Mahadle

Abstract: In recent time, breast cancer has ranked number one cancer among Indian females and became the leading cause of women death. Now a days, there has been an extraordinary progress in the researches related to breast cancer resulting into so many more efficient treatments. The GSTP1 gene polymorphism can increase the risk of breast cancer due to reduced conjugating activity of the gene. Increased expression of the CYP19A1 gene in breast cancer cells leads to higher oestrogen production, making it a good candidate for treatment. The Brca1 and Brca2 genes play vital roles in DNA repair and cell cycle regulation, and any mutation can lead to cell transformation and cancer development. High expression of the STK11 gene has been linked to breast cancer and identified as a potential target for treatment. From ancient times, number of common medications are derived from medicinal plants. There are so many phytoconstituent extracted from plants which are successfully proved for the treatment of severe diseases like cancer, diabetes, heart diseases. If we use herbal plants for treatment of diseases there are fewer toxic effects seen. Turmeric (Curcuma Longa), Garlic (Allium sativum L.), Curry leaves (Murraya koenigii), Bhumi Amla (Phyllanthus niruri), Mushroom (Agaricus bisporus), Ashwagandha (withania somnifera), Mango (Mangifera indica L.) are the phytoconstituents extracted from this herb are used as an effective treatment to treat breast cancer without any side effects. This review paper has covered the epidemiology, types, causes, stages, signs and symptoms, treatments of breast cancer and the use of different types of herbs in treatment and management of breast cancer.

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