A Current Analysis of Synthesis and Pharmacological Effects of Benzimidazole Derivatives (Research Article)

Author(s): Joshny Varghese*, Anju V, Santhosh M Mathews and Justin Jacob Thomas

Abstract: Benzimidazole is an important heterocyclic organic compound having structural analogy to nucleotides found in human body and profound pharmacophore in medicinal chemistry. It is a bicyclic aromatic organic compound which is a fusion of benzene and imidazole ring. Generally, benzimidazole derivatives are synthesized by reaction of o-phenylenediamine with various carboxylic acids. It has been an exciting area of pharmaceutical chemistry to research the biological evaluation of benzimidazole derivatives. In this review article, various synthetic methods of benzimidazole derivatives and their pharmacological activities were described.

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