INVESTIGATION, FORMULATION AND EVALUATION OF ANTIDIABETIC TABLET OF PUNICAGRANATUM PEEL

Author(s): Ghodke Amol D1*, Jain Shirish P, Ambore Sandeep M, Shelke Satish P and Bochare Umesh J

Abstract: The present study was aimed to formulate & evaluate the antidiabetic tablet of Punicagranatum peels waste. Hyperglycemia is the most common metabolic endocrine disorder. It is the chronic condition in which blood glucose level is elevated than normal due to the improper insulin production in body or due to insulin resistance, high blood glucose level and low blood glucose level leads to diabetic condition. Allopathic treatment for diabetes mellitus is too costly so focus on herbal medicines is necessary. Pomegranate peels or rind are considered as an waste material these peels consists of numerous important active chemical constituents such as flavonoids, vitamins and minerals. The main principle active chemical constituents including punicalagin, punicalin, β-sitosterol and valoneic acid dilactone (VAD) from pomegranate peels powder shows potent antidiabetic activity Punicagranatum peels extract have stability problem than other dosage form by converting it into tablet dosage form. We enhance its acceptability, elegance and patient compliance. Manufacturing of tablets was done by using wet granulation method on lab level tablet press (CEMACH) by wet granulation method. Evaluations tests performed on tablets such as Hardness, Weight variation, friability, disintegration test etc.,

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