ANTIDIABETIC ACTIVITY OF DIFFERENT LEAF EXTRACTS OF CASSIA TORA IN ALLOXAN INDUCED DIABETIC RATS

Author(s): Swaroopa Rani. Vanapatla and Anuradha. S*

Abstract: In traditional medicine leaves of Cassia tora (Leguminosae) are used as laxative, antifungal and antibacterial activity. Some biological reports on seeds revealed, it has antidiabetic activity. Present study was carried out to strengthen antidiabetic activity of Cassia tora leaves. Leaf powder was extracted with petroleum ether, chloroform, ethyl acetate, methanol and water successively by maceration. Phytochemical screening of those extracts was carried out. And found to contain amino acids, flavonoids, steroids, alkaloids, saponins, tannins and glycosides. All extracts Petroleum ether extract (PE), Chloroform extract (CE), Ethyl acetate extract (EE), Methanol Extract (ME), and Aqueous extract (AE) were screened for antioxidant activity by Reducing power method and Hydrogen peroxide method. Among all the extracts, ethyl acetate extract exhibited strong activity, Methanol and Aqueous extracts gave moderate activity which is also comparable with Ascorbic acid. Hence EE, ME and AE were screened for antidiabetic activity by alloxan induced method. Glibenclamide was used as standard drug (mg/kg b. w.) EE, ME and AE showed significant activity in the dose dependent manner comparable with Standard. All the three extracts ethyl acetate, methanol and aqueous extracts were found to increase the glucose tolerance in the order EE > ME > AE.

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