BIOSYNTHESIS OF NANOSILVER AND ITS EFFECT ON THE INSOLUBILITY OF SIMVASTATIN

Author(s): K. M. Karande* and S. P. Gawade

Abstract: Aim: Metal nanoparticle-drug interaction is indeed merely explored area of research and guarantees some effective outcomes pertaining to improvement in biopharmaceutical characteristics essential for its therapeutic value. The present investigation was performed with the end objective of solubility enhancement of Simvastatin by a novel technique. Methods - The present investigation reported a green method for synthesis of nanosilver (NS) using Coriandrum sativum (CS) leaf extract. Synthesized NS were subsequently evaluated for its effect on the insolubility of Simvastatin. Synthesized NS were evaluated by visual observations, UV-Visible spectroscopy, Transmission Electron Microscopy, IR spectroscopy, zeta potential, and phase solubility study. Results - Color transformation was observed as an indication of the formation of NS. UV-Visible spectroscopic analysis revealed surface plasmon resonance at 437nm. TEM of NS showed spherical shape and size distribution was significantly in the range of 150 to 200 nm. SAED pattern showed diffused rings pattern. IR supports the evidence of the interaction favorable to enhance the adsorption of Simvastatin on NS. Zeta potential study also supports the evidence of adsorption phenomenon. Phase solubility study was carried out in and off a presence of NS which revealed that an increase in the concentration of NS proportionately increases the solubility of Simvastatin. Conclusion - Various drugs may have the potential to get adsorbed on NS / Silver nanoparticles, thus enhancing their biopharmaceutical characteristic. Present investigation supports the preliminary pieces of evidence which showed, the solubility of Simvastatin may be enhanced by adsorption phenomenon using silver nanoparticles.

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