FORMULATION AND IN VITRO EVALUATION OF ORAL COLON TARGETED TABLET OF PYRANTEL PAMOATE

Author(s): B. Sirisha* and M. Ajitha

Abstract: In the present study it has been aimed at developing pH sensitive tablets of Pyrantel Pamoate for local action in proximal colon, with a view of minimizing the drug release in the physiological environment of stomach and small intestine and to ensure maximum drug release in the physiological environment of proximal colon with an improved patient compliance, least side effects, better drug therapy and all aspects of an ideal drug delivery system. Twenty seven formulations (F1-F27) were prepared by wet granulation method using 33 Response surface method where 33 indicates 3 variables and 3 levels of natural polymers of different ratio Okra Gum, Tamarindus Indica and Gum Kondagogu (low, middle and high concentrations) by using Design of experiment software. The Preformulation properties were carried out and the values obtained were within the range. And FTIR studies results revealed that there was no incompatibility between drug and excipients. Thus, colon Tablets were formulated by varying proportions of polymers by wet granulation method and they were evaluated. All the physico-chemical properties of the formulations were within the limit. The formulation F26 was selected as optimized formulation because it showed minimum release in stomach and small intestine and a maximize release in proximal colon. In vitro drug release studies were carried out to know the drug release with respective of the time. Maximum drug was released from the formulation F26 within 24 Hrs. Based on the physico-chemical properties and in vitro drug release, the formulation F26 was concluded as the best formulation. No prominent changes in physico-chemical properties of formulation after its exposure to accelerated conditions of temperature (40±20C) and humidity conditions (75 ± 5%RH) were seen. Hence the developed formulation was found to be stable even after subjecting to accelerated stability conditions.

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