FORMULATION AND CHARACTERIZATION OF PALIPERIDONE LOADED MUCOADHESIVE MICROEMULSION FOR INTRANASAL DELIVERY

Author(s): Tulasi Ashwin Kumar and Anil Goud Kandhula

Abstract: Paliperidone (PPD) is used for the treatment and management of schizophrenia. The present study demonstrates the potential of mucoadhesive microemulsion of PPD for nasal delivery. PPD-MME was prepared by water titration method, prepared formulations were subjected to physicochemical characterization, and evaluated for size, zeta potential, PDI, pH and stability studies. The microemulsion, containing 5% oleic acid (oil Phase), 40% surfactant mixture of Tween 80(surfactant): Transcutol HP (cosurfactant) (2:1) and 55% aqueous phase, that displayed globule size of 94.8±0.34nm, a PDI of 0.25±0.22 and zeta potential was 14.5±0.4 mV, chitosan was selected for the incorporation of polyelectrolytic polymer as the mucoadhesive component. The mucoadhesive microemulsion formulation of Paliperidone that contains 0.5 % by weight of chitosan.

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