SYNTHESIS AND ANTI-INFLAMMATORY POTENTIAL OF OXADIAZOLE DERIVATIVES OF NSAIDS

Author(s): Surya Pratap Singh*, B.K Singh, Versha Percha

Abstract: The present investigation was undertaken with the aim to synthesize oxadiazole derivatives of NSAIDs, by selecting ketoprofen as drug moiety. Ketoprofen was too converted into its conversion to hydrazide. The synthesized hydrazide of the ketoprofen was then treated with POCL3 and certain selected (aliphatic and aromatic) acids were substituted for the designing of four compounds viz. A, B, C, D. All the synthesized derivatives were then characterized on the basis of UV, FTIR and 1HNMR spectral data. The 4 analogues were synthesized to ascertain the affectivity of the substituted oxadiazole derivatives on anti-inflammatory efficacy that illustrated good anti- inflammatory activity as compared to the standard drug. Evaluating the synthesized analogues pharmacologically assured the activity of derivatives.

PAGES: 539-543  |  40 VIEWS  171 DOWNLOADS