INVESTIGATION OF ROLE AND CONSERVATION OF INSULIN RECEPTOR SUBSTRATE 2 PROTEIN

Author(s): Meenu Sharma and C.S. Kapoor

Abstract: Insulin receptor substrate (IRS) proteins have indispensible role signalling via insulin and insulin receptors interactions. The IRS 2 is one of the members of IRS family. In this study we explored the phylogenetic conservation and evolution of IRS 2 protein while involving statistical analysis and algorithms. IRS 2 is not only an alternate means to fight off diabetes but also play a crucial role in various types of cancers. To have a better understanding of evolution of IRS 2 and its direct and indirect role in other pathways, it’s very important gain useful information of closely related species. Numerous methods including statistical analysis were employed to find its probability of occurrence. The study provides a rapid way to study evolution and make confident predictions to speed up the future research.

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