GLUCOSE METABOLISM AND CYCLOOXYGENASE ACTIVITY IN BRAIN OF STZ INDUCED DIABETIC RATS TREATED WITH CURCUMIN

Author(s): Bhaskar Nagilla*, Bharathi and Pratap Reddy K

Abstract: The objective of this research was to study the glucose metabolism and cyclooxygenase metabolism in brain of rats and amelioration of curcumin treatment. This study reports the effect of curcumin (200mg/kg per body wt., / day) on polyol pathway, pentose pathway, Cyclooxygenase metabolism and histological alterations in hippocampus and cerebral cortex of rat with STZ induced diabetes for 3 weeks. Metformin (150mg/kg body weight) was used as standard reference drug. The activities of aldose reductase (AR); sorbitol dehydrogenase (SD) Cyclooxygenase (COX), PG peroxidase were increased whereas the activities of the Glucose 6-phosphate and Na+K+ATPase activity were decreased, and glucose and sorbitol content were increased in diabetic rat brain. The significant decrease AR and SD with curcumin treatments shows its protection against diabetic complications. Decreased COX and PG peroxidase suggests its protections against inflammation. STZ-induced brain damage in the cortex and regions within the hippocampus was seen but histological alterations induced by diabetes in Brain were restored with Curcumin treatment. These results suggest that Curcumin exerts, efficiently, an attenuating effect on the progression of hyperglycemia and also some hyperglycemia-induced complications in rat brain, when compared to Metformin.

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