SMILAX CHINA ETHANOLIC EXTRACT ON ATTENUATED BEHAVIOURAL IMPAIRMENTS, NEUROCHEMICAL DEFICTS AGAINST MPTP INDUCED PARKINSON’S DISEASE IN RAT

Author(s): B. Sabari Senthil* and V.K. Kalaichelvan

Abstract: The present investigation was aimed to analyse the ethanolic extract of S. china (EESC) on the Behavioural Impairments, neurochemical variables against MPTP induced rat model of Parkinson’s disease (PD). Except control group, all animals received 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) daily administered for 7 days through intraperitoneally at doses of (30 mg/ kg of body weight, dissolved in saline, to induce PD. Later the animals, were divided into five groups for each plant extracts as; two test groups, one control group, one negative control and one standard group. The test group received 150 mg/kg of body weight of EESC and 300 mg/kg of body weight of EESC. The total time duration of the study was 14 days for each extract i.e. 28 days to complete the study. Treatment with EESC at doses of 150 and 300 mg/kg of body weight in PD rats improved the behavioral irregularities found in the vehicle and MPTP administered group (P< 0.05). Treatment of EESC at 300 mg/ kg of body weight showed reduced to start movement (akinesia) and muscle rigidity or failure to modify an externally forced position (catalepsy).This was more significant of improvement in locomotor activity on 20th day of treatment with EESC at 300 mg/ kg of body weight when compared between levodopa and carbidopa treated group (P < 0.001) and showed dose dependent efficacy for EESC. On 7th day, EESC at 150 and 300 mg/ kg of body weight administered groups, i.e. groups III and IV, showed significant rise in retention time (P <0.001) when compared with MPTP administered group. The Passive avoidance test was employed to study foot shock stimulus. Repeated treatment with MPTP (group II) has decrease in latency time when compared with control group. Administration of EESC at both doses at 150 and 300 mg/ kg of body weight administered groups, i.e. groups III and IV with MPTP administered rats significantly (P < 0.005) increased latency period when compared with MPTP induced group. Findings of the present study revealed that EESC may help in reducing the risk of developing Parkinson’s disease (PD).

PAGES: 690-700  |  40 VIEWS  154 DOWNLOADS