SYNTHESIS, SPECTRAL CHARACTERISATION AND PHYSIOCHEMICAL PROPERTIES DETERMINATION OF SUBSTITUTED {4-(1H-BENZIMIDAZOL-2-YL) PHENYL} DIAZENYL DERIVATIVES

Author(s): KNV Chenchu Lakshmi* and Rama Rao Nadendla

Abstract: Conventional synthesis of substituted {4-(1H-benzimidazol-2-yl) phenyl} diazenyl derivatives had been synthesized at laboratory scale by diazotization followed by coupling with different phenols and amines. The compound structures were characterized by IR, H1 and C 13 NMR spectroscopic methods. The synthesis was followed by chemical calculations by using Chemicalize an online software providing chemical calculations and predictions like logP, PKa and solubility mg/mL. The results observed describes that values of intrinsic solubility are less than zero which indicates that the compounds were categorised with low aqueous solubility. The isoelectric points for the compounds 8s (4.57), 7s (5.70) and other compounds having values ranging from 6.03 to 8.70 representing the pH at which the molecule carries no net charge required to predict the solubility of a compound.

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