PHARMACOGNOSTICAL STUDIES AND ANTIMICROBIAL ACTIVITY OF THE LEAVES OF Sophora interrupta Bedd.

Author(s): S. Shaheen, M. Khajapeer and B. Kavitha*

Abstract: Aim: The present study mainly focuses on the establishment of pharmacognostical studies and antimicrobial activity of Sophora interrupta leaves. It is a woody perennial shrub which grows endemically in Seshachalam hills of Thirumala, India. The plant was investigated and was found out to possess anti- cholesterolemic, anti- inflammatory, abortifacient, antibacterial, anti-spasmodic, diuretic, emetic, emollient, febrifuge, hypotensive, purgative, styptic and tonic properties. Methods: The powder of S. interrupta was successively extracted with aqueous, acetone, alcohol, benzene, chloroform, ethyl acetate, methanol and petroleum ether for pharmacognostical studies and antimicrobial activity. Results and Conclusion: Extractive values of leaf yielded highest amount in aqueous 20.80 w/w. Leaves yielded highest number of secondary metabolites as alkaloids, phenols, glycosides and saponins, tanins and lignins in most of the extracts. Antibacterial activity of leaf aqueous and methanol extracts showing more effective activity on E. coli with 29.50; 24.75 mm zone of Inhibition than other extracts. Minimum Inhibitory Concentrations with leaf extracts at 0.25 to 2.52 mg; compared to that of the 10 mg of Ampicillin. Antifungal activity of leaf benzene and chloroform extracts were more effective on C. albicans with 12.75; 12.50 mm zone of inhibition than A. niger when compared to Nystatin the control drug at 10 mg/well with 10.2 to 12.1 mm of zone of inhibition. From this study we can conclude that the traditional use of this plant for the treatment of infectious diseases is promising alternate supplement against pathogenic bacteria.

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