Antioxidant Effect of Vitamin-E Treatment on Hexavalent Chromium Induced Hepato and Renal Toxicity in Laboratory Chicks

Author(s): Vandita Kandpal and Dharmendra Kumar*

Abstract: Protection against metal toxicity has been a centre of attraction for industrial hygienists, public health officials, toxicologists and pharmacologists. Hexavalent chromium compounds have been shown to manifest toxic and carcinogenic effects in humans and animals. Since the discovery of the fact that oxidative damage is one of the mechanisms responsible for their toxicity, the use of antioxidants was considered to be a suitable alternative. Antioxidants restricted the uptake and distribution of chromium in liver and other organs. It is well established that vitamin E act as an antioxidant against toxicity induced by different heavy metals. Keeping this in view, present study has been carried out to investigate the protective effects of vitamin E on renal and hepatic enzymes in chicks against toxicity induced by hexavalent chromium. Developing chicks (Croiler, body weight 100±20 gm) were used as experimental animals. The serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and creatinine enzymatic activity parameters were selected for the study. Significant decrease of serum (ALT), (AST), (ALP) and creatinine were observed in purely chromium treated groups, while, these values were significantly increased in vitamin E treated groups as compared to chromium treated group. Hence, it may be concluded that the progressive hepatorenal toxicity of hexavalent chromium can be moderately reduced by administrating vitamin E in laboratory chicks.

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