Synthesis and Evaluation of Some New (E)-5-((E)-4-((E)-Benzylidene amino) Benzylidene) Thiazolidine-2,4-Dione Analogs as Aldose Reductase Inhibitors

Author(s): Neelam Khan, Girendra Gautam and Arun K. Gupta

Abstract: Aldose reductase (ALR) enzyme plays a significant role in conversion of excess amount of glucose into sorbitol in diabetic condition through polyol pathway and responsible for the secondary complications. Thus, the inhibition of aldose reductase has basic approach to the prevention and treatment of diabetic complications. In this work we described the synthesis and the functional evaluation of a series of substituted (E)-5(4-aminobenzylidene) thiazolidine-2,4-dione (Ta 01-11) were synthesized and tested for in vitro aldose reductase inhibitory activity. ARI activity of synthesized compounds was found in the range of38.29-69.12% at 10 μg/mL. Similarly, synthesized compounds decrease blood glucose level in the range of130.20-173.20mg/dl at 15 mg/kg body weight. Hence (E)-5-((E)-4-((E)-benzylideneamino)benzylidene) thiazolidine-2,4-dione derivatives newer analogs shows comparable ARI as well as antidiabetic activity and devoid from the toxicity.

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