Antiproliferative Effect of Rhus Succedanea, Rheum Emodi and Gardenia Gummifera in Prostate PC-3 Cells

Author(s): Sirangala Thimappa Girisha

Abstract: In the present study antioxidants activity of Rhus succedanea, Rheum emodi and Gardenia gummifera determined by SOD activity which is increased and suggests that it exhibit highest superoxide anion-scavenging ability with an inhibition rate of more than 90 percent and has an efficient protective mechanism in response to ROS, in Anti-inflammatory assay lipoxygenase activity which is dose dependent response by displaying inhibitory potential at an IC50 of 25.58μg/ml, in hyaluronidase inhibition assay the results shows that the activity is dose-dependent manner with IC50 of 29.34μg/ml and the phytochemical analysis by GCMS analysis shows the presence of myristic acid vinyl ester, vinyl decanoate, tridecanoic acid which act as chemo preventive agents against prostate cancer.

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