Process for The Separation of the (Dl) Cis-Trans-2, 2-Dimethyl-3-(2, 2-Disubstitutedvinyl)-Cyclopropane-1-Carboxylic Acid from Its Optical Isomers

Author(s): Vijaykumar L. Chavan* and Swati S. Jaydeokar

Abstract: The present work relates to a new process for separating the two optical isomers of optically active 2, 2-dimethyl-3(2, 2-disubstituted vinyl)-cyclopropane carboxylic acid using R-N-(1-napthylmethyl)-∝ -methyl benzyl amine and it’s enantiomer S-N-(1-napthylmethyl)-∝ -methyl benzyl amine.Thus, the resolving agent of the present work can be prepared and also can be recovered from the reaction mixture after the resolution reaction in a high yield and further shows excellent resolving effect, and hence, it is a promising resolving agent. Further the resolution process is optimised by using suitable non-polar solvent to enhance enantiomeric excess. A method of present invention, wherein (±)-cis or (±)-trans-cypermethric acid is reacted with a resolving agent; the resultant diastereomer salt is separated from the reaction mixture; the separated diastereomer is treated first with a base and then with an acid to obtain resolving agent. It is accordingly an object of the proposed work to provide a process for optically resolving (±)-trans- cypermethric acid to obtain intended products of high purity in high yield at low costs.

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