Synthesis, Characterization, and Antimicrobial Activity of Schiff Bases Derived From 4, 6 - Difluoro - 2 - Amino Benzothiazole

Author(s): Raksha V. Zala and Surbhi V. Upadhyay

Abstract: Some novel Schiff bases namely N-(4-(dimethyl amino)benzylidene)-4,6-difluoro benzothiazole-2-amine; 4-bromo-2-(((4,6-difluoro benzothiazole-2-yl) imino) methyl)phenol and N-(3,4-dimethoxybenzylidene)-4,6-difluoro benzothiazole-2-amine have been synthesized from condensation reaction of 4,6-difluoro-2-amino benzothiazole with different aromatic aldehydes like 4-(dimethyl amino)benzaldehyde, 5-bromo-2-hydroxy benzaldehyde and 3,4-dimethoxy benzaldehyde . The synthesized Schiff bases were characterized by elemental analysis, FT-IR, Mass and 1H NMR spectroscopy. Antimicrobial and Antifungal activities of these Schiff bases were tested using MIC determination against gram positive (S. Aureus, B.Subtilis), gram negative bacteria (S. Marcescens, E. Coli) and Rhizopus sp. and A. Niger.

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