In-Vitro Cytotoxicity and Anthelmintic Evaluation of Various Synthesized Novel Imidazoles

Author(s): Rohit Kumar*, Vikas Saxena, Abhishek Kumar Saxena, M. Hoque

Abstract: Synthesized novel imidazole derivatives as potential therapeutic agents for in-vitro cytotoxicity and anthelmintics. Firstly, Pyridine-2-amine was condensed with substituted benzaldehydes to give corresponding Schiff’s base. These Schiff’s bases further on treatment with Ammonium acetate and isatin yielded corresponding novel imidazoles. The synthesized compounds were analyzed by physical & analytical methods. The synthesized compounds were evaluated for in-vitro cytotoxicity activity and anthelmintic activity. All the synthesized novel substituted imidazoles showed moderate to good anthelmintic activity. It also possessed significant in-vitro cytotoxicity against HEp2 cell lines (Human larynx cancer cell line) against standard using 5-fluorouracil. The compounds 1b, 2b, 4b, 6b and 8b possessed higher anthelmintic activity in comparison to standard Mebendazole. The synthesized compounds 1b, 2b, and 8b possessed significant in-vitro cytotoxicity against HEp2 cell lines.

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