Beneficial Effect of Extracts of Momordica charantica, Emblica officinalis, Tribulus terrestris and Trigonella foenum Graecium in Combination against Streptozotocin Induced Diabetic Nephropathy

Author(s): Vir Vikram and Sandeep Kaushal

Abstract: Present study evaluates the synergistic effect of Momordica charantica, Emblica officinalis, Tribulus terrestris and Trigonella foenum graecium in combination on the streptozotocin (STZ) induced diabetic nephropathy (DN) rats. Diabetes was induced in all the animals by single intraperitoneal (i.p.) injection of STZ at a dose of 55 mg/kg. Animals were treated STZ + MC + EO group which receives STZ + Momordica charantia (250mg/kg) + Emblica officinalis (250mg/kg); STZ + MC + EO+ TT group which receives STZ + Momordica charantia (250mg/kg) + Emblica officinalis (250mg/kg) + Tribulus terrestris (250mg/kg); STZ + MC + EO+ TT+TF group which receives Momordica charantia (250mg/kg) + Emblica officinalis (250mg/kg) + Tribulus terrestris (250mg/kg) + Trigonella foenumgraceium (250mg/kg); STD group which receives lisinopril 1 mg/kg for the duration of 28 days. Effect of MC+EO+TT+TFG was determine by estimating blood glucose level and body weight on 1st, 14th and 28th day of protocol. Biochemical parameters of renal function, level of oxidative stress and histopathology was also determined for the estimation of synergistic effect of MC+EO+TT+TFG treatment on the STZ induced DN rats. Result of the study suggests that treatment with MC+EO+TT+TFG ameliorates the altered level of blood glucose and body of STZ induced diabetic nephropathy. Moreover, level of parameters of oxidative stress and renal function was also found to be attenuated in MC+EO+TT+TFG treated STZ induced diabetic nephropathy rats. Histopathology study also suggests that TS of kidney tissues of MC+EO+TT+TFG treated rats show improvement compared of DN rats. In conclusion, data of the study reveals that treatment with MC+EO+TT+TFG in combination shows potential effect for the management of DN by reducing oxidative stress.

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