In silico Design of Anti-Tyrosinase Small Peptides for Skin Lightening Therapeutics

Author(s): Usha Rani. J, Siva Prasad. B, Vutukuru. S.S and Chand Pasha

Abstract: Peptides from natural origin are found to be effective in treating skin related disorders including hyperpigmentation. These peptides have potential to inhibit tyrosinase enzyme function thereby reduce melanin synthesis. Hence present study is aimed at evaluating antityrosinase function of small peptides that were identified from literature and experimental results. 3D structure of human tyrosinase was designed using SWISS MODEL. PROCHECK and Verify-3D tools were used to validate the 3-D model. Flexible docking of small peptides with human tyrosinase protein was carried out using CABS – dock server. Based on Cluster density and average RMSD values, small peptides showed an interaction between human tyrosinase and peptide residues with distances less than 5.5 Å. Thus, it was concluded that small peptides that were screened for antityrosinase activity in the study enable further experimentation in establishing their efficacy in regulating tyrosinase function.

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