Chrysin Prevents Deregulation of Collagen Expression and Renal Renin-Angiotensin System in L-Name Induced Hypertensive Rats

Author(s): Dominic Amalraj Arul anandu, Veerappan Ramanathan, Mahalaksmi Sethu and Malarvili Thekkumalai

Abstract: Aim: Hypertension is a major risk factor for cardiovascular mortality and morbidity through its effects on target organs like the brain, heart and kidney. To evaluate the effect of chrysin, a natural biologically active compound extracted from many plants, mushrooms, honey and propolis on the blood pressure, collagen type I and III gene expression and Mg levels in Nω‑nitro‑L‑ariginine methyl ester (L‑NAME)‑induced hypertensive rats. Materials and Methods: Hypertension was induced in adult male albino rats of the Wistar strain, weighing 180-220 g, by oral administration of L‑NAME (40 mg/kg BWT/day) in drinking water for 4 weeks. Rats were treated with chrysin (25 mg/kg BWT/day) for 4 weeks. Results: In our results shows Collagen type I and III gene expression, Mg levels in plasma and brain, and renal fold changes of Angiotension Converting Enzyme (ACE) increased significantly in the plasma of hypertensive rats. Supplementation of chrysin restore collagen type I and III gene expression, Mg and renal fold changes in ACE in Group IV compare to group I. Conclusion: These results suggest that chrysin has enough potential to attenuate hypertension and renal damage in nitric oxide deficiency induced hypertension.

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