PHARMACOLOGICAL EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF HORDEUM VULGARE

Author(s): Mohammad Zubair Shareef, *Gummadi Sridhar Babu and P. S. Malathy

Abstract: The present study was the main objective to assess the hepatoprotective activity of hydroalcoholic extract of root of Hordeum vulgare. LD50 studies were conducted in albino rats with hydroalcoholic extract of root of Hordeum vulgare according to OECD guideline No.423 and were found safe upto the dose level of 2gm/kg confirming its non-toxic nature. The Hepatoprotective activity was studied in carbon tetra chloride, paracetamol and ethylene glycol induced hepatotoxic animal model. The biochemical parameters like serum SGPT, SGOT, albumin, decreases and total protein increases with hydroalcoholic extract of root of Hordeum vulgare root confirmed the hepatoprotective effect of extract under this study. In liver injury models in rats restoration of hepatic cells with minute fatty changes and absence of necrosis after treatment with extract was observed, indicating satisfactory hepato protection. Mainly based on the improvement in serum marker enzyme levels it was concluded hydroalcoholic extract of root of Hordeum vulgare possesses significant hepatoprotective activity in the doses used.

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