HEPATOPROTECTIVE ACTIVITY OF PASTINACA SATIVA, EXTRACT AGAINST ACETAMINOPHEN INDUCED HEPATIC DAMAGE IN RATS

Author(s): Arun Kumar Sanapala* and K. Eswar Kumar

Abstract: Pastinaca Sativa has been traditionally used in Indian medicine as a result of its curative results of hepatitis, gonorrhea and diabetes; it is probably not proof-founded. However, folklore has given us many powerful therapies, based on plant sources. So claims which can be made for the protective efficacy of Pastinaca Sativa (family: Apiacea) to treat hepatic diseases. The present study focused on investigating the role of alcoholic extract of Pastinaca Sativa. It appreciably prevented the increased in serum Aspartate amino transferase (AST), Alanine amino transferase (ALT), alkaline phosphatase (ALP) and Total serum bilirubin (SB) level in acute liver damage by Acetaminophen and elevated the activities of lipid peroxidation (LPO) and glutathione (GSH) in the liver. Histopathological observation of the liver used to be additionally performed to further support the evidence from the biochemical analysis. The observation that these significant protective effect against acute hepatotoxicity induced by Acetaminophen of Pastinaca Sativa.

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