Synthesis, Characterization and in vivo Anti-Inflammatory Activity of Some Novel Schiff’s Bases of Isatin Derivatives

Author(s): Sudhakar. B* and M. Srinivasa Murthy

Abstract: In the present study, a series of novel Schiff bases of Isatin derivatives are incorporating different 5-sustituted N-benzyl Isatin derivatives with benzimmidazole derivatives (3a-3h) and with tryptamine (4a-ah) were synthesized and characterized by FTIR, 1H-NMR, Mass spectroscopy. Further, the compounds were screened for in vivo anti-inflammatory activity by carrageenan induced paw edema method. The tested compounds have shown mild-to-moderate anti-inflammatory activity at dose of 10 and 20 mg/kg when compared to that of 10 and 20mg/kg dose slandered drug. the anti-inflammatory effect of compound 3e (55.9, 69.0), 3f (58.9, 77.4) and 4c (57.3, 73.2), 4e (51.3, 81.2) and 4g (50.5, 78.3) at 10 and 20mg/kg and Diclofenac sodium 63.5, 86.5 at 10 and 20mg/kg was found to be similar. The higher anti-inflammatory activity of compound 4j and 4n could be due to presence of higher hydrophobic planar substitutions.

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