Formulation and In-Vitro Characterization of Paliperidone Nanosuspension by using Nanoprecipitation

Author(s): M. Sreenivasulu Reddy, J. Sreeramulu*, Y. Narendra Reddy, G. Rammohan

Abstract: The main aim of present research is to formulate Nanosuspension of Paliperidone to improve the solubility and bioavailability. Paliperidone nanosuspension was prepared by Nano precipitation method using various stabilizers such as SLS, Tween80, Pluronic F127, PVP K30 and methanol. All the prepared formulations entrapment efficacy was found to be in the range of 83.74%-97.15% respectively. IR spectroscopic studies indicated that there are no drug-excipient interactions. When compared to other all the formulations F9 is the best formulation which showed 97.41% of drug released respectively with in 20 min and follows Zero order release kinetics.

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