In vivo and In vitro Models for Biological Screening of Anti-Diabetic Drugs

Author(s): R. Vijayaraj, N. Sri Kumaran* and Swarnakala

Abstract: The secondary metabolites have been traditionally used for diabetes treatment throughout the world; few of them have been validated by scientific criteria. The need for alternative strategies for the prevention and treatment of diabetes is growing rapidly as type-2 diabetes is accomplishment epidemic status in our society. The developing for novel bioactive compounds with antidiabetic properties to deal with the disease condition is still in progress. In the present review, we have attempted to bring together all the reported models for screening antidiabetic drugs using In vivo and In vitro models and the various in vitro techniques which include Inhibition of α-Amylase, α-Glucosidase activity and glucose uptake assay. Experimental induction of diabetes mellitus in animal models and in vitro techniques are essentials for the advancement of our knowledge, clear understanding of diabetogenic and for finding new therapy. The animal models and in vitro techniques are essentials for developing a new drug for the treatment of diabetes. The purpose of this review article is to describe the significance of animal models available for screening of antidiabetic activity.

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