In silico Docking Studies of Novel Pyrazole Derivatives for Glaucoma

Author(s): K. Banupriya, R. Girija and S. Aruna

Abstract: Purpose: To explore newer computational approaches in the design of novel CAS inhibitors for the treatment of glaucoma. Methods: An in-silico molecular docking was utilized to design a novel CAs inhibitors for the treatment of glaucoma. The designed novel molecules were theoretically evaluated to predict their pharmacokinetic properties and toxic effects. Lead molecules were screened out in virtual screening technique on the basis of low binding energies obtained in AutoDock based molecular docking simulation. Results: Out of ten top lead compounds screened, ZINC01729523 and ZINC04692015 were promising, having shown potent inhibition of myocilin, good pharmacokinetic properties and absence of any toxic effects. Conclusion: Docking studies of molecular libraries containing a large number of ligands is very useful for short-listing of potential lead molecules for further structure-based discovery of antiglaucoma-drugs.

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